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Although Hara and Kimura (2000) pointed out that lithological differences, deformation, hydrothermal alteration, and weathering are the controlling factors for IC value, we first focused on the effect of deformation and fragmentation due to the faulting before moving on to examine the other effects such as hydrothermal alteration on the basis of bulk-rock mineralogy.
External water is identified as the main cause of alteration on the basis of the models and other evidence.
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However, reports showing differences in the occurrence of these alterations on the basis of tumour characteristics have been scarce.
Predicted ORF sequences were manually reviewed and alterations were made on the basis of the presence of potential ribosomal binding sites, sequence alignments and available literature data.
The program needs to be calibrated (trained) in such a way that it recognizes possible alteration in the ORFs on the basis of their statistical properties [ 16].
Four missense and two deletion variations were selected for this study because they were expected to cause functional alterations on pol ι on the basis of the nature of the changes, positions in the pol ι catalytic core, and predicted effects.
An important advantage of a level A correlation is that, since an in vitro dissolution/release curve is used as a surrogate for in vivo performance, changes in manufacturing conditions, raw material suppliers or minor formulation alterations may be justified on the basis of in vitro data, rather than in vivo bioavailability studies.
In this work, the ratio of NADH/NAD+ and the pool concentrations of ATP and Pi were all changed through the alteration of acetic acid pathway on the basis of academic analysis.
Although the methylation level did not show any significant alteration among the groups categorized on the basis of clinicopathological features such as tumor grade or tissue position but were invariably higher in glioma patients compared to the control patients (data not shown).
The response after combination therapy was monitored on the basis of alteration in the course of parasitaemia, the extension of mean survival time and the percent cure rate in different groups.
For example, as a consequence of cardiac infarction or ischemia, different patterns of dyskinesia may occur and consequently pharmacological treatment may be evaluated on the basis of alteration of heart dynamics.
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