The phrase "alteration of transcript" is correct and usable in written English.
It can be used in contexts related to changes or modifications made to a written record or document, particularly in academic or legal settings.
Example: "The alteration of transcript was necessary to correct the errors found in the original document."
Alternatives: "modification of transcript" or "revision of transcript".
A correlation between alteration of transcript levels and corresponding proteins was detected for half of the differentially regulated proteins.
Further modifications, including alteration of transcript splicing sites, modification of codon usage patterns, and the introduction of introns into TMV coding sequences, have improved protein expression further.
In addition, ectopic expression of this gene altered plant development including plant height, internode length, and size of leaves and flowers, accompanied by alteration of transcript abundance of the gibberellin biosynthesis-related gene GA2OX3.
This partial loss of imprinting results in alteration of transcript dosage of chromosome 12-imprinted genes, and the mice are viable and fertile (Schuster-Gossler et al., 1998; Sekita et al., 2006; Steshina et al., 2006).
RT-PCR analysis showed that steady-state mRNA levels of these genes were higher in the transgenic plants compared with those of WT in the absence of water stress, in line with earlier reports in which overexpression of a TF resulted in extensive alteration of transcript levels of an arsenal of related genes [ 33, 34].
However, such a pro-angiogenic pattern of SSc-MVECs is counterbalanced by up-regulation of pent(r)axin 3, a powerful angiogenesis inhibitor, by down-regulation of a few critical pro-angiogenic transcripts (three tissue KLKs, plexin-B1, and DSG), and by alteration of transcripts involved in signal transduction pathways.
Candidate genes with a P-value threshold of 0.05 are presented in Table 3. qPCR analysis confirmed significant alteration of transcripts encoding α1-antitrypsin, α2-macroglobulin, fibrinogen α, immediate early-response genes Egr-1 and IER-5, pro-inflammatory cytokine IL-32, and hypoxia-related bHLH transcription factors Hes-1, DEC1 and DEC2.
Instead, it can also involve weak but consistent alterations of transcript abundance.
This design is well suited to study length-dependent alterations of transcript abundance due to RNA degradation and imperfect amplification.
Transcriptome studies have shown that large scale alterations of transcript abundances is a common feature of Fe deficiency and thus plays a key role in the Fe deficiency response [ 15- 17].
In darkness, constitutive activation of GNA1 or GNA3 causes minor or no alteration of cellulase transcript levels, whereas in Δ env1 the initially strong transcription of the major cellobiohydrolase gene cel7a (cbh1) at 48 h, significantly drops at 72 and 96 h upon growth on cellulose (Castellanos et al., 2010; Schmoll et al., 2005, 2009; Seibel et al., 2009).
