The phrase "alteration of the functioning" is correct and usable in written English.
It can be used in contexts discussing changes or modifications to how something operates or works.
Example: "The alteration of the functioning of the system was necessary to improve efficiency."
Alternatives: "change in operation" or "modification of functionality".
Instead of a cause-effect relationship, the improvement in both cognitive functions might be due to the direct or indirect (trans-synaptic) alteration of the DLPFC functioning.
A recent functional study provided evidence for an alteration of the function of the ATP-sensitive potassium channel in the β-cell, encoded by KCNJ11 and ABCC8, when these two variants were coexpressed [ 77], possibly explaining previous inconclusive reports of investigations of a single mutation.
We used this assay system to evaluate the effect of an alteration of the function of ATMSH2, the Arabidopsis homologue of MSH2, on microsatellite stability.
We replaced the two loops with segments of random amino acids, and used mRNA display to isolate variants that specifically recognize adenosine triphosphate (ATP), demonstrating a significant alteration of the function of this protein domain from DNA binding to ATP recognition.
The first hypothesis takes into account the well described alteration of the function of the major Pi transporter, Mir1p, when a single cysteine residue is modified (see Additional file 5).
Alteration of the function of key components of the TGFβ/Smad signaling by using RNA interference or decoy ligand traps approaches impairs the formation of breast cancer metastasis in experimental models [ 16, 25, 26].
This silencing effect contributes to an alteration of the function of genes located near the ring fusion point by modulating (mainly downregulating) their expression in a telomere-dependent fashion [ 10, 16- 18].
Interventions that modify emotional attention may thus plausibly be mediated by alteration of the function of either the amygdala or the prefrontal biasing signals; the effects of the interventions on attention would be predicted to be reflected in altered sensory and association cortex activation to emotional stimuli.
This could occur either through acetylation-dependent alterations of the function of non-histone proteins, including transcription factors such as STAT380, or by metabolite changes that could result from decreased acetate availability.
APE1 gene polymorphisms may lead to amino acid substitutions, which may result in alterations of the functions of APE1/Ref-1.146.
