The phrase "alteration of systemic" is correct and usable in written English.
It can be used in contexts discussing changes or modifications to systemic structures or processes, often in fields like medicine, sociology, or organizational theory.
Example: "The alteration of systemic factors is crucial for understanding the overall impact on public health."
Alternatives: "modification of systemic" or "change in systemic".
In 12 patients, the palliative strategy was modified (alteration of systemic chemotherapeutics, induction or abandonment of radionuclide therapy).
Our first objective was to determine if alteration of systemic microvascular function can occur after pulmonary PM exposure at levels that fail to cause gross pulmonary toxicity.
However, alteration of systemic blood pressure (BP) or ocular blood flow (OBF) also seems to be involved in the disease process [ 11].
Furthermore, the alteration of systemic levels of miRNAs can perturb the homeostasis of circulating miRNA and disturb normal functions in cells and tissues and thus create unwanted side effects.
The high corticosterone levels also demonstrate that the phenotype observed is unlikely to be related to an alteration of systemic glucocorticoid levels since excessive bone formation occurred despite the higher circulating glucocorticoid levels.
Moreover, alterations of systemic immunity has been reported in NPC patients [ 39, 40].
However, how induced Brms1 in cancer cells via alterations of systemic SK1/S1P modulates their lung colonization/metastasis remains unknown, and need to be determined.
Whether alterations of systemic or cerebral circulation might play a role in sepsis-induced encephalopathy, however, has not yet been determined.
Data from the present study indicate that pulmonary exposure to ROFA or TiO2 resulted in similar alterations of systemic microvascular function.
Therefore, we first examined whether alterations of systemic S1P in response to systemic loss of SK1 is involved in the regulation of S1PR expression in tumours, which might then controls Brms1 expression.
Overall, these data suggest a mechanism by which cancer cells communicate with the host through alterations of systemic S1P signalling to regulate lung colonization/metastasis via controlling tumour S1PR2/Brms1 axis (Fig 9).
