The phrase "alteration of stem" is correct and usable in written English.
It can be used in contexts related to linguistics, biology, or any field where the concept of changing or modifying a stem is relevant.
Example: "The alteration of stem in the plant species resulted in a significant change in its growth patterns."
Alternatives: "modification of stem" or "change of stem".
Knowledge gained from these studies portends the alteration of stem cell fate in the absence of biological factors, which would be valuable in the engineering of complex organs comprising multiple cell types.
To examine whether this alteration of CD24 expression in the colon of DBZ-treated mice was paralleled by an alteration of stem cell activity, we studied Lgr5 mRNA levels in the isolated fractions of colonic crypts.
The difference in the relative frequency of CD44+/CD24- and ALDH1+ cells between basal-like and HER2+ tumor subtypes may reflect their distinct cell-of-origin or the alteration of stem cell-like gene expression programs due to tumor subtype-specific transforming events [ 39].
Thus, additional studies are warranted to increase our understanding of progerin-induced alterations of stem cell functions.
Furthermore, virtually all stem cells imaging technologies require some degree of ex vivo alteration of the stem cells prior to implantation of the cells, and so efficiency of alteration is also a requirement.
It has been recently suggested that any alteration of the stem cell homeostasis by constant and repetitive trauma, and chronic disease could provoke a persistent disequilibrium inside the stem cell reservoir leading to an irreversible and premature decrease of the stem cells regenerative potential reducing their "stemcellness" [ 2].
In particular, mutations that lead to the alteration of the stem cell division pattern or the acquisition of some degree of immortality in committed progenitors lead to an early onset of cancer and diminish the impact of genetic instability.
However Kreso et al. described a new therapeutic way to downregulate the BMI1-related self renewal without alteration of normal stem cells [55].
As we demonstrate below, the results in Essers et al (2009) suggest that the application of IFN α induces an impaired self-renewal ability of HSCs, potentially due to the stimulated proliferation and an alteration of the stem cell niche interaction.
The alteration of the stems to make RSA measurements possible may also affect the migration especially migration in the distal direction.
Alterations of the stem design like the so called anatomically adapted stems which are designed for a proximal force transmission are not able to reduce the proximal bone resorption significantly, as shown by Venesmaa et al. [ 19].
