The phrase "alteration of specificity" is correct and usable in written English.
It can be used in contexts discussing changes in the level of detail or precision in information or data.
Example: "The alteration of specificity in the research findings led to a broader interpretation of the results."
Alternatives: "change in specificity" or "modification of specificity".
For example, Matton et al. [ 35] demonstrated alteration of specificity using mutagenesis experiments involving these hypervariable regions.
Motivation: Recognition models for protein-DNA interactions, which allow the prediction of specificity for a DNA-binding domain based only on its sequence or the alteration of specificity through rational design, have long been a goal of computational biology.
Attempts have been made to realize this goal via directed evolution of phiC31 integrase, but were ultimately not able to achieve significant alteration of specificity (Keravala et al., 2009; Sclimenti et al., 2001).
In this connection, we have conducted several site-specific chemical modification studies with human lysozyme for the purpose of both the alteration of substrate specificity [ 12] and the clarification of the origin of carbohydrate recognition specificity [ 13].
Nevertheless, studying phenotypic changes following alteration of relative specificity at a larger scale, as shown in Figure 1A, will fundamentally enhance our appreciation of relative specificity and its regulation of biological systems.
The advantages of STXM include less radiation damage to the chromosomes compared to electron microscopy and without alteration of chemical specificity due to the stains.
Most of the mutants result in alteration of catalytic specificity, yielding both galactooligotetrasaccharide (GOS4) and galactooligotrisaccharide (GOS3) compared to the sole product GOS3 by the WT.
Interpretation of the effect of the replacement of Asp167 to Glu on the alteration of substrate specificity in relation with the predicted 3D model of PQQGDH-B is also discussed.
Although the engineering of glycosyltransferases is still in its early stages, recent work on the structure-based alteration of substrate specificity and the manipulation of glycosyltransferase profiles in whole cells to effect complex changes in in vivo glycobiology probably foreshadows a wave of considerable innovation in this area.
Therefore, it is likely that the positive selection exerted here during evolution resulted in alteration of substrate specificity of MelD2.
Arboviruses adapt readily to new susceptible hosts by alteration of receptor specificity, transmission efficiency, antigenicity, and ecological and environmental conditions.
