Sentence examples for alteration of signalling from inspiring English sources

These anti-correlations may indicate that alteration of signalling through the IGF axis may create selective pressure against acquiring certain other aberrations.

Elevated synaptic acetylcholine levels result in persistent receptor stimulation and the alteration of signalling pathways with functional changes at tissue/organism level [ 29].

The cytotoxic effects of contrast media have been assessed by studying both tubular cytotoxiticy and alteration of signalling molecules in cultured human renal proximal tubular epithelial cell line.

To assess the alteration of signalling pathways in drug-sensitised DUSP6-depleted cells in an unbiased fashion, we measured levels of phosphoproteins by solid-phase antibody array.

Epigenetic inactivation of such transcription factors may affect multiple downstream genes, causing aberrant alteration of signalling pathways involved in a wide array of cellular functions, including growth, differentiation and apoptosis.

Under the assumption of linear relationship between transcript and protein levels, differential gene expression could give a clue of protein deregulation and of the alteration of signalling cascades to which they belong.

Changing some cellular energy metabolic pathways, such as glycolytic flux, or genetic alteration of signaling pathways may substantially affect the PPP.

It has been recognized that genetic mutations in specific nucleotides may give rise to cancer via the alteration of signaling pathways.

Another possibility involves alteration of signaling in distinct cellular compartment(s).

It appears that heterodimerization in response to chemokine binding is required for the termination or alteration of signaling by an increasing number of chemokine receptors [13].

A major finding in our studies is the unexpected profound alteration of signaling pathways in monocytes from patients treated with tremelimumab.