Sentence examples for alteration of regulation from inspiring English sources

Among the presumed main advantages of polyploidy are fixation of heterosis, duplication enabling evolution of gene function, and alteration of regulation.

This suggested that our disrupted network represents two broad adaptive mechanisms that may be at play in both our model and the human tumour data: alteration of transcriptional regulation in response to loss of AR regulation (seen in Fig.  4); and altered signalling driving proliferation and inhibiting cell death.

The PanK isoforms are feedback regulated by CoA thioesters [4], [5], [7], and the loss or alteration of feedback regulation by mutations in PanK result in dysregulated CoA production [5], [8].

This susceptibility to organ failure would be related to an alteration of the regulation mechanisms of the systemic inflammatory response.

The agency and the White House argued that because the proposed changes didn't constitute a significant alteration of a regulation or policy, HUD didn't need to request public comment about the deleted certification requirement, according to people briefed on the internal deliberations.

A potential mechanism of the rs842647 effect is alteration of gene regulation.

It implies that the interactions between these two TFs result in the alteration of RAV1 regulation on HMG1 gene.

Interestingly, M2 was enriched for terms associated with chromatin modification, suggesting a developmental alteration of epigenetic regulation.

A second mechanism is provided through alteration of gene regulation imparted through mutation in cis-acting elements and/or alterations of trans-acting factors.

Consequently, disruption of RXR function, the putative exclusive heterodimer partner of NRs, could cause alteration of gene regulation and the reported malformations.

Fluorescence binding assays indicate a significant loss of binding and alteration of enzyme regulation for individual mutants of these surface residues (E16, F17, and E20).