The phrase "alteration of melatonin" is correct and usable in written English.
It can be used in contexts discussing changes or modifications in melatonin levels or production, often in relation to sleep or circadian rhythms.
Example: "The alteration of melatonin levels can significantly impact sleep quality and overall health."
Alternatives: "change in melatonin" or "modification of melatonin".
The role of melatonin in the susceptibility to these disorders remains unclear, but an alteration of melatonin as a powerful antioxidant molecule and/or as a "Zeitgeber" (time giver) could alter and/or desynchronize many physiological processes related to a broad range of disorders.
Melatonin is involved in the regulation of numerous body functions, and alteration of melatonin levels and, therefore, circadian rhythms (e.g., light at night), has been implicated in breast cancer and mammary tumors in humans and rodents (Stevens and Rea 2001), as well as immune system suppression, depression, and other neurological disorders (Malhotra et al. 2004).
Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression.
Buxton, O. M., Lee, C. W., L'Hermite-Baleriaux, M., Turek, F. W. & Van Cauter, E. Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase.
Alteration of the melatonin pathway has been reported in circadian disorders, diabetes and autism spectrum disorders (ASD).
163, 164 Patients with metabolic syndrome have disturbances in melatonin production, characterized by an alteration of the night melatonin-insulin ratio of unclear clinical significance.
This trend raises the hypothesis that alterations in the metabolism of melatonin may play an important role in the development of delirium [ 10].
Melatonin plays an important role in the regulation of the sleep-wake cycle, so this raised the hypothesis that alterations in the metabolism of melatonin might play an important role in the development of delirium.
The circadian system gets disturbed by exposure to light at night, leading to alterations in sleep patterns, suppression of melatonin production and deregulation of circadian genes involved in cancer-related pathways (Stevens et al, 2007).
Oral administration of EA extract at 200 mg/kg p.o. normalized these stress induced oxidative alterations with an efficacy similar to that of melatonin.
After oral dosing, the Cmax is affected by the solubility of melatonin in the formulation, alterations in bioavailability, and clearance.
