However, the common "intra-chain" scrambling is not expected to affect the outcome of HDX MS/MS measurements presented in this work; only interchain proton hopping would result in alteration of the measured deuterium content of the fragments produced by dissociation of the disulfide bond.
There is a great unmet need for this type of analytical approach in metabolomics, as well as in the other -omics fields (e.g. transcriptomics), which allows the quantification of alterations at the biological systems (pathways) level rather than simply identifying significant alterations of discrete measures (i.e. single metabolites).
Decreased validity of the effect measure in epidemiological studies can be regarded as introduced in four hierarchical steps – confounding, misrepresentation, misclassification and analytical alteration of the effect measure [ 1].
This implies that the alterations of PPS measured after cortical lesions or tactile coactivation are controlled by other mechanisms than those involved in changes induced by environmental enrichment or aging.
The features computed in critical bands based on the reference concept include the partial loudness of the emotional difference, emotional difference-to-perceptual mask ratio, measures of alterations of temporal envelopes, measures of harmonics of the emotional difference, the occurrence probability of emotional blocks, and perceptual bandwidth.
For the first transition, a typical alteration of spatiotemporal and kinematic measures can be seen in Fig. 4B,C,E,G and Fig. 5A,B,N.
To test if ATBC inhibited incision by intercalating into the DNA substrate, we monitored DNA intercalation by an assay that measures alteration of the topology of relaxed, covalently closed circular plasmid.
To determine whether H2O2-induced oxidative stress alters mitochondrial bioenergetics in ONH astrocytes and whether CoQ10 treatment inhibits the alteration of mitochondrial bioenergetics, we measured cell viability, ROS generation and cellular ATP level.
To understand such a relation, we developed an experimental setup and measured alteration of leaflet microstructure in response to pressure increase in porcine tricuspid valves using the small angle light scattering technique.
Finally, to demonstrate that Se accumulation results in the alteration of presynaptic plasticity we measured PPF in hippocampal slices of wt mice treated or not with Se.
