Human agency also fosters the alteration of large-scale drivers of change at the local level.
Diffusion weighted imaging studies have shown alterations of large white matter tracts, most notably in left temporal lobe epilepsy, but the degree of altered connections between cortical and subcortical structures remains to be clarified.
We observed that TC-PTP +/− mice were more sensitive to DSS treatment than TC-PTP+/+ mice as shown by histopathological alterations of large bowel, increased cytokine expression in serum and cytokine signaling in the large bowel.
However, even the earliest lesions showed marked alterations of large domains as seen in the later cancers.
Furthermore, we observed some large methylation changes that were specific to one or a few twin pairs (Supplementary Material, Table S5), suggesting that some rare epigenetic alterations of large effect may be associated with psychosis.
In the early 1980s, the architect David Gura oversaw a radical conversion of the Pythian Temple into apartments, a devilishly complicated alteration because of large beams, the windowless facade, and double-height lodge and other rooms.
Alterations of larger chromosome segments were found in tolerant cells including losses (5p, 6, 9, 12p and 21q) and gains (5q, 10, 11, 12p, 13q and 18q) in Line2-T500, as well as losses (3p, 7q, 11q, 16q and 17q) and gains (1q, 3q, 4p, 5p, 8q, 11, 17q, 18q and 22q) in Line3-T200 (Table 1).
Stone shattering led to flattening and deep alteration of a large part of the original karstic landscape and to demolition of drystone walls.
The significant alteration of a large number of transcription factors could cause profound effects on chloroplast biogenesis and/or other processes.
According to change of phase space behaviour and alteration of three largest lyapunov exponents, it was observed that simulated normal persons act as chaotic systems in stride production, but simulated PD does not have chaotic dynamics and is stochastic.
Proteomics and difference gel electrophoresis (DIGE) permit simultaneous assessment of alterations in large numbers of proteins [ 19].
