Sentence examples for alteration of known from inspiring English sources
Another possibility explaining the function of p30 involves the binding and alteration of known cellular proteins involved in RNA modification and transport.
Alteration of known substrate affinities was taken as evidence that the A302R, F336R, L339R, G872R, F942R, Q946R, V982R, S993R, and M986R mutations were at drug binding locations.
Two of three patients (66%) with long term CR (28.7+ and 23.6+ months) (cases #1 and 3) had a BRAF mutation as the only molecular alteration of known significance and one of seven patients (14%) with transient CR/PR had only a BRAF mutation (case #6).
Most patients (n = 7) had multiple additional alterations of known oncogenic significance (Table 2).
Seven of ten patients (70%) had somatic alterations of known significance in addition to BRAF mutations (Table 2).
(PDF 9017 kb) Additional file 2: Additional Tables S1-S8: Copy number alterations of known genomic locations identified in HNSCC cell lines.
Another patient (case #6) with a biopsy 31��months prior to treatment had only a BRAF mutation among the alterations of known significance.
The results from a sample obtained 26 months after treatment initiation, however, showed no BRAF mutation, or other molecular alterations of known significance.
The molecular alterations were reported as somatic alterations of known significance and somatic alterations of unclear significance based on the impact of these molecular alterations on tumorigenesis as stated in the scientific literature.
One patient with an ongoing CR of 23.6+ months duration (case #3) had NGS analysis performed on a biopsy obtained 53 months prior to treatment; no alterations of known significance were demonstrated.
I also retrieved the most likely mode of action of each driver TF upon alterations in tumorigenesis (either activating, LoF, or undetermined) across approximately 4,000 TCGA samples, determined by a random forest classifier trained on the pattern of somatic alterations of known drivers [ 14].
