Sentence examples for alteration of key from inspiring English sources

Resistance is often associated with 1) inhibition of alteration of key enzymes that are targets for antimalarial drugs or 2) alteration of drug accumulation into the parasite which results from reduced uptake of the drug, an increased efflux, or a combination of the two processes.

In addition to the fragmentation of mitochondrial morphology noted above, there are many other factors which could contribute to the profound alteration of key aspects of mitochondrial function following their isolation.

Among underlying causes of cancer is accelerated or deregulated proliferation, with alteration of key cell cycle regulators and perturbation of proliferative negative retrocontrols such as cell cycle checkpoints or DNA damage response.

Collectively, these data suggest that compromised insulin secretion in Rfx6-deficient β cells is the consequence, at least in large part, of the combined alteration of key steps in glucose signaling due to a failure of Rfx6 to directly promote the expression of key genes.

Our results further suggest that the alteration of key parameters of the histone code depend upon inhibition of the DNMTs, and DNA hypermethylation mediated by DNMTs may be essential for maintaining a particular combination of histone modifications at gene promoters silenced with aberrant DNA methylation.

Since the level of several transcripts involved in the MHC class I presentation pathway (MHC class Ia, TAP1, TAP2, PSMB8 and PSMB9) decreased, it is possible that PrV has developed complementary strategies to evade this pathway i.e. turning off the peptide pump with inhibition of TAP activity and transcription alteration of key players [ 5].

There was, in other words, the sense of repeating verses but with it subtle and not-so-subtle alterations of key and detail to fit the mood swings of the texts.

This review describes the recent advances in our understanding of the genetics of ALL, with an emphasis on those alterations of key pathogenic or therapeutic importance.

Changes in the thymic stromal compartment and alterations of key signaling pathways in thymocytes result in an aberrant development and the lack of regular T cells.

Alterations of key elements of the apoptotic pathway have been shown to be determinant in the outcome of NBLs.

Therefore, detailed understanding of the alterations of key matrix proteins is essential in deciphering the mechanisms of LV remodelling after MI.