The phrase "alteration of gut" is correct and usable in written English.
It can be used in contexts discussing changes or modifications related to the gastrointestinal system, such as in medical or health-related discussions.
Example: "The alteration of gut microbiota has been linked to various health issues, including obesity and diabetes."
Alternatives: "modification of gut" or "change in gut".
Arimatsu, K. et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota.
PEM increased both nonspecific total IgA and oral antigen-specific IgA in serum without alteration of gut permeability.
Our study has further proved the efficacy of VSL#3 in reducing atherosclerotic plaque development, drawing importance to the alteration of gut microbial profile.
Alteration of gut commensal bacteria has consistently been associated with increased risk of obesity related liver disease [e.g., nonalcoholic fatty liver disease (NAFLD ], with a dysbiotic microbiome frequently observed among obese individuals with NAFLD (Turnbaugh et al., 2009).
Guelinckx et al. [14] found that digestive alteration of gut contents, together with the additon of excretory products, represented approximately 9% and 12%, respectively, of the total diet to tissue discrimination observed in P. minutus (6.6‰ for ΔN and 6.66‰ for ΔC).
One of the few studies examining isotopic alteration of gut contents relative to diet during both ingestion and digestion by Guelinckx et al. [14] suggested that alteration is likely to be small compared to the total discrimination between diet and tissue, especially where fore-gut contents are analysed.
Similar considerations suggest the potential importance of alterations of gut absorption [24], [25] resulting in changes of energy excretion in urine and feces which were not directly measured in the present study, but were included in our calculations of energy output.
Such alterations of gut homeostasis can facilitate infections (Garrett et al. 2010; Clemente et al. 2012).
Exposure to PCBs also resulted in alterations of gut permeability via decreased expression of TJ proteins in an intact physiological animal model.
Future research in this area should quantify how interindividual variations in gut microbiota affect the body burden of environmental chemicals by altering a) these chemicals directly, b) the level and activity of host phase I and II enzymes, c) enterohepatic circulation of environmental chemicals, d) depletion of host detoxification capacity, and e) alterations of gut barrier function.
In this context, when evaluating the effectiveness of vitamin D supplementation in the course of MS, one should consider the eventual polymorphisms affecting the VDR, which has been recently associated with obesity, inflammation, and alterations of gut permeability (Al-Daghri et al., 2014).
