Sentence examples for alteration of gap from inspiring English sources

In the present study we wanted to elucidate the structural bases, if any, that determine whether or not a mutant would undergo proper trafficking to cell membrane and, if trafficked properly, whether or not it would lead to complete or partial alteration of gap junction channel conductance.

For quite a long time the loss or the alteration of gap junction intercellular communication (GJIC) was proposed to play an important role in the process of carcinogenesis [ 28], in particular, when occurring in animal models as well as in human during hepatocarcinogenesis [ 29, 30] and after animal exposure to tumor promoting agents [ 31].

A recent publication by Chung et al. further demonstrated that a deletion of RARα leads to an alteration of gap-junction-based cell coupling (Chung et al., 2010).

Interestingly, changes of IENF density are often associated with alterations of GAP-43.

Whether alterations of GAP-43 are per se (and causally) associated with sensory changes such as pain or sensory abnormalities is currently unknown.

This suggests that commercial arrays may miss chromosomal alterations because of gaps between probes.

(3) To the best of our knowledge we report for the first time that women with prior CABG had comparable inhospital outcome to men despite the fact that they were older and had worse baseline clinical characteristics, which suggests a role of prior CABG history in the alteration of the 'gender gap phenomenon'.

Although the effects of acute ischaemia on human cardiac gap junctions are difficult to investigate directly, studies on experimental animals demonstrate rapid dephosphorylation of Cx43, electrical uncoupling and alteration in the distribution of gap junction immunolabel to the sides of the myocyte (referred to as 'lateralization').

Genome alteration print (GAP) of (A) AW8507, (B) AW13516, (C) NT8e AND (D) OT9 cell lines obtained by SNP array.

Remodelling may take the form of alterations in (i) the distribution of gap junctions and (ii) the amount and type of connexins expressed.

These shifts in light quality mediate many of the subsequent community changes following gap formation, and we contend that gap formation by phytophagous insect removal of a foundation canopy species may exhibit light quality alterations that differ drastically from that of other forms of gap formation.