Sentence examples for alteration of either from inspiring English sources

Histone deacetylases can regulate expression of tumor suppressor genes and activities of transcriptional factors involved in both cancer initiation and progression through alteration of either DNA or the structural components of chromatin.

In contrast, alteration of either Asp38 or Asp104 (to either Ala or Asn) gave wholly inactive mutants.

The temporal-spacial alteration of either type of GABAergic synapses after CNS injury and the effect on OPCs and posttraumatic remyelination are not yet clear.

Alteration of either charged or hydrophobic interactions between the enzyme and the substrate, particularly in the −3 subsite, changed and/or broadened the substrate preferences of Chit42.

In a further 695 cases, a segmental alteration of either chromosome 1p and/or 11q and/or 17q was observed, and these cases were termed segmental genomic type.

However, tumor cells are able to escape from the control of this cytokine in the early tumor stages; this could be due to a decreased expression of IFNγ, or also to an alteration of either its receptors.

Alterations of either tissue will modulate the properties and functions of other parts of the osteochondral junction [ 20].

In our investigation, a higher rate of serum p53Abs was found in patients with the worst lung function alterations of either obstructive or restrictive type, thus confirming that p53Abs may be associated with patients at increased risk of lung cancer.

Although strong alterations of either of these signaling pathways can cause adverse effects, including embryonic lethality, cancer, and diabetes, milder downregulation can be beneficial for health and longevity in all organisms so far tested (Piper et al., 2008).

The overall strategy was to determine binding at a single subsaturating ligand concentration to enable the detection of changes that originate in alterations of either K d (dissociation constant) or Bmax (maximum binding).

Indeed, in previous studies, 155 out of 175 cases with a segmental genomic type without MNA, and 43 out of 48 infants with a segmental genomic type without MNA, had alterations of either chromosome 1p, and/or 11q, and/or 17q (Janoueix-Lerosey et al, 2009; Schleiermacher et al, 2011).