Sentence examples for alteration of downstream from inspiring English sources

However, the mechanism underlying the alteration of downstream signaling due to such mutation has not yet been completely understood at the system level.

Thus, we propose that the filamentous life style in F. depauperata could be the result of an alteration of downstream signaling components in the filamentation pathway.

Mutations within homeodomains are significant as subtle changes in DNA binding affinity could have important biological affects due to the alteration of downstream gene activation or repression.

The potential negative feedback on the GnRH system in response to the alteration of downstream patterns of the brain pituitary gonadal axis is then suggested, although the mechanism underlying the modulation of neuroendocrine systems by BPA has not been clarified.

Lots of studies have shown that aberrant Wnt signaling pathway is involved in carcinogenesis, in fact, alterations of downstream components in Wnt pathway have been found in a series of human cancers.

The mechanism of eQTL regulation functions as a bridge between upstream genetic variation and downstream phenotypes; eQTL can control the transcript expression of functional genes through DNA binding, mRNA splicing, and noncoding RNA expression in transcriptional regulation, thereby conferring the alterations of downstream phenotypes [ 17].

Indeed, in addition to high expression of the receptor, EGFR-1 signalling may be upregulated by increased expression of its ligands, activating receptor mutations, heterodimerisation with other members of the family such as HER-2, and alterations of downstream molecules in the signalling pathway.

The alteration of the downstream hydrological regime is a well established cause of ecological degradation and its evaluation and rehabilitation is commonly required by recent legislation (as the Water Framework Directive in Europe).

It is not known whether a stepwise chain of epigenetic events occurs during hypoxia, ie changes in DNA methylation occurring before histone modifications and alteration in expression of downstream mi-RNAs.

We conclude that the mechanisms of rapamycin resistance in hepatic cells involve alterations of signaling downstream from mTOR and that the mechanisms are highly heterogeneous, thus predicting that maintaining or promoting sensitivity will be highly challenging.

This indicated that the transduced fragment had caused alterations of genes downstream from crp.