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Moreover, for each study participant the number of discrepancies between pre-admission and discharge medication (i.e. temporary or permanent introduction or withdrawal of a drug, alteration of dose and/or frequency including switching between regular and pro re nata application schemes, therapeutic drug substitutions) was determined.
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Treatment is provided to patients considering pharmacological interactions between medications of three illnesses: alteration of doses of medications and/or MDR-TB regimen itself, if required.
Numerous studies have reported photon/electron backscatter and alteration of the dose by high-density implants, but we know of no evidence of a dosimetry phantom that incorporates high density implants or fixtures.
Alteration of the dosing schedule of daptomycin according to a PK-PD target enabled effective use of this unique drug while averting musculoskeletal toxicity, whereas more recently an area under the curve/minimum inhibitory concentration target derived from the neutropenic mouse thigh model for vancomycin in staphylococcal bloodstream infections has been supported in large clinical cohorts.
Exposure to multiple chemicals may cause significant alterations of tissue dose of the toxic moiety of one or more of the individual chemicals.
One might consider these genes to be involved in hepatotoxicity; however, all three of the profiles indicate that the gene expression alterations are independent of dose in the liver, and one profile shows similar changes in the kidney as well.
Alteration of the injected dose of photosensitiser did not produce a clear difference.
The treatment changes include alteration of the radiation dose, prevention of inappropriate radiation therapy and a change in intent in terms of curative versus palliative radiation therapy.
Although lower blood pressure may be beneficial in many contexts, it is a concern that likely reflects physiological alterations of low-dose exposures to pesticides in children.
A post hoc analysis of the effect of certain presumed side effects of rosiglitazone (edema, elevated transaminases) upon medication dose reductions showed that the rate of dose alterations due to liver transaminase elevations differed in the M + R group.
During follow-up, thyroxine dose remained unchanged in 35.4%, and a further 31% and 21% of cases required a dose alteration of 25 μg and 50 μg respectively during long term surveillance.
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