The investigation on gene signatures and alterations of distinct cell subpopulation in heterogeneous pools of adult NSCs in relation to aging may bring a new strategy for revealing novel mechanisms for stem cell aging.
Furthermore, alterations of distinct metabolic pathways were detected which offer novel insights into the switch of individual metabolite pattern along with the decline in insulin sensitivity.
Overall, G × E was abundant and frequently large in magnitude, presenting a pattern in which different genetic backgrounds responded to fluctuations in copper exposure through alterations of distinct transcriptional programs.
Moreover, our specific characterization of peripheral alterations to distinct subsets of immune cells may provide biomarkers for diagnosing and characterizing the degree of TBI severity, progression and/or recovery.
Another possibility involves alteration of signaling in distinct cellular compartment(s).
Under this scenario, it can be postulated that recognition of fungal elicitors would trigger alterations in the expression of distinct miRNAs which are responsible of reprogramming host developmental processes, including auxin-regulated processes.
30 A number of distinct alterations have been identified including point mutations within the nucleotide-binding loop in exon 18, small deletions in exon 19 or insertions in exon 20, as well as point mutations in the activation loop in exon 21.
Wu P, Ma LG, Hou X, Liu F, Deng XW. (2003) Phosphate Starvation Triggers Distinct Alteration of Genome Expression in Arabidopsis Roots and Leaves.
Strahler, J., Berndt, C., Kirschbaum, C. & Rohleder, N. Aging diurnal rhythms and chronic stress: Distinct alteration of diurnal rhythmicity of salivary alpha-amylase and cortisol.
The late-summer hurricane season entails an annual alteration of consciousness and a distinct set of rituals: laying in supplies, taping windows, deciding how much to trust official admonitions.
