Sentence examples for alteration of differentiation from inspiring English sources

Suprabasal expression of integrin beta 1 in epidermis has been attributed to hyperproliferation of keratinocyte, alteration of differentiation, inflammatory response and pathogenesis of psoriasis [33].

Lef1 represents another main effector of this pathway in HF morphogenesis; indeed, Lef1- null mice lack hair coat, and transgenic mice overexpressing inactive forms of Lef1 present severe alteration of differentiation and HF cell fate.

Inhibiting these pathways, in the context of pancreatitis, causes increased cell death and prevents the resolution of metaplasia (Fendrich et al., 2008; Siveke et al., 2008), implying that small molecules targeting Notch or Hedgehog will have pleiotropic effects, including the alteration of differentiation states.

A corresponding definition for in vitro test systems would be 'specific alterations of differentiation in the absence of overt (unspecific) cytotoxicity'.

Immunocytochemistry of the shRNA knocked down transplanted neurons in the recipient brains showed no compromised cell cycle exit and no alterations of differentiation.

Conversely, disturbed Lef1 signalling results in alteration of the differentiation programme in keratinocytes promoting sebocyte differentiation (Merrill et al, 2001; Niemann et al, 2002).

As mentioned in the section "T-cell activation and differentiation", under some inflammatory conditions, alteration of Th differentiation is one of the factors contributing to disease development or progression.

Through in vitro model, our study here has revealed that the age related alteration of the differentiation potential of MSCs is dependent on the external differentiation cues.

Here we describe a novel biological role for the KP and report that IFN-γ-induced IDO activation in MSCs leads to impaired proliferation and an alteration of their differentiation capacity.

PGC-1 α deficiency induced alteration of the differentiation program and an induction of muscle degeneration that was exacerbated by the co-transfection with siPINK1.

The observed changes in Rpreg were not secondary to an overall alteration of the differentiation program, as testified by the lack of effect of the genetic maneuvers listed above on the secretion of hCG.