In other words, those approaches do not allow a dynamic analysis that evaluates the risk for each alteration of the context.
These findings challenge the potential for cancer therapies aimed at transient oncogene inactivation, at least under those circumstances where tumour cell differentiation and alteration of epigenetic context fail to reinstate apoptosis.
Second, at least under those circumstances where tumour cell differentiation and alteration of epigenetic context would not be predicted to reinstate apoptosis and no alternative mechanism exists for tumour cell removal, sustained inactivation of the offending oncogene would seem the desired therapeutic goal.
Thus, we would challenge the potential for cancer therapies aimed at transient oncogene inactivation, at least under those circumstances where tumour cell differentiation and alteration of epigenetic context fail to reinstate apoptosis and no alternative mechanism exists for tumour cell removal.
Therefore it is highly possible that mutations in ORC could potentially modulate a subset of gene expression via the alteration of chromatic contexts, which in turn results in the developmental defects seen in MGS.
It is possible that alteration of DCPS in a context were SMN is fully functional in all tissues negatively impact on the balance of DCPS/SMN activities with detrimental consequences on neuronal functions.
This indicates that, at least in a whole genome context, alteration of either CP or dinucleotide frequencies had no significant effect on viral polyprotein translation and therefore cannot be attributed to the marked differences in replication phenotypes observed.
This implies that sense-to-sense genetic code alterations are accompanied by alteration in the context (upstream and downstream) of the codons that change identity to maintain amino acid triplet signatures (amino acid context).
The inclusion criteria for the immunohistochemistry were atheromatous alteration of the carotid artery in context with the clinical need of carotidectomy.
These results suggest that Smads may be present in large, multi-protein complexes which regulate mature miRNA levels through alteration of miRNA processing in a context dependent manner.
We also discuss the implications of these alterations in the context of HIV-1 infection and in light of current concepts of TCR signal transduction.
