It is the process of inhibition, stimulation, modification, regulation or therapeutic alteration of activity, electrically or chemically, in the central, peripheral or autonomic nervous systems.
As one can judge from the plot, the LTP was caused by the activation of previously silent proximal synapse 1, while the distal synapse 2 did not show substantial alteration of activity.
However, such a severe alteration of activity would be predicted to have far-reaching effects on Rab7-dependent pathways.
The extreme high temperature would induce specific membrane damage, expression of HSP [ 49], and alteration of activity of enzymes, which was not prevalent at moderate heat stress [ 50].
Our findings suggest that the alteration of activity and stability of acetylcholinesterase are at the origin of the fitness cost associated with mutations providing resistance.
Fifty-three percent of the recorded neurons showed significant alterations of activity during mastication.
For technical reasons having to do with the relative ease of manipulation of activity levels in vitro, most previous studies involving externally imposed alterations of activity were performed on developing neurons in culture systems.
Further analysis of this effect in the LabMaster system revealed that the reduction of BW, which in NPY−/− PYY−/− mice persisted for the whole observation period of 15 days, cannot conclusively be explained by alterations of activity and food intake.
The specific alteration of these activities should constitute a further source of novel analogues.
Different sugar moieties could also result in alteration of biological activities, as observed in rebeccamycin (Animati et al. 2008).
Because the curing involves rearrangement of structural proteins and cross-linking of the proteins for stability, alteration of enzyme activities could change the properties of the glue.
