Sentence examples for alteration of action from inspiring English sources

The T wave alternans, a repeating ABABAB variability pattern in the morphology and amplitude of the T wave, reflects heterogeneity of repolarization and arises from beat-to-beat alteration of action potential duration at the level of cardiac myocytes, serves as a mechanism of arrhythmogenesis, and expresses vulnerability to lethal ventricular arrhythmias [ 59].

Adaptive behaviors require preparation and when necessary inhibition or alteration of actions.

Our results showed significant alteration of postural actions between pre- and postoperative stages and between 6 months and 1 year after surgery.

The alteration in modes of action supports a key role of the n-loop extension in assembling functional surface of CITDs for membrane disruption.

Taking advantage of the cubic ternary complex model, and mathematically modeling our results, we hypothesize that this alteration in ligand mechanism of action is consequence of a change in ligand-induced conformational rearrangement of receptor and its effect on G-protein coupling.

It is expected that if the incubation time is increased, the growth inhibition would also increase without much alteration in the mechanism of action [63].

Using flow cytometry and high-resolution fluorescent microscopy, it was observed that dimerization and tetramerization of the Chex-Arg20 monomer led to an alteration in the mechanism of action from non-lytic/membrane hyperpolarization to membrane disruption/depolarization.

Published data suggests that clinically relevant TP-drug interactions (TP-DI) are likely from overlap in mechanisms of action, alteration in target and/or drug-disease interaction.

The changes in HPA3 behavior with the introduction of Pro likely reflects alterations of the mechanism of action: i) HPA3 forms pores in the bacterial cell membranes, ii) HPA3P permeates the cell membranes and binds to intracellular RNA and DNA, and iii) HPA3P2 acts on the outer cellular membrane component LPS.

In addition to the alteration of markers of androgenic action, the endocrine feedback loop (mainly the hypothalamic– pituitary target organ axis) could also be affected by BPA, showing no compensatory mechanisms of increased LH or FSH.

We conclude with the suggestion that our approach and the resulting data indicate a novel mechanism of SNP action: alteration of the functional characteristics of the proteins through phosphorylation may significantly contribute to our understanding of the molecular basis of complex diseases, such as cancer.