The phrase "alteration not only" is not correct as it is incomplete and lacks the necessary continuation to form a proper expression.
It is typically used in the context of a comparison or contrast, often followed by "but also" to introduce an additional point.
Example: "The alteration not only improved the design but also enhanced functionality."
Alternatives: "change not only" or "modification not only".
If an alteration not only fixes the problem at hand but also allows the research programme to make a novel prediction, then the alteration is said to be progressive.
We confirmed that the epigenetic alteration not only of the CpG sites within the CpG island located on the promoter region of exon 1, but also of those distributed throughout the gene, exhibit a relationship with depressive symptoms.
TP53 is unique among tumor suppressor genes because its alteration not only results in loss-of-function of the product, but also generates a range of mutants demonstrating a gain-of-function phenotype.
These alterations not only prevent the formation of a hexamer but also distort the active site geometry resulting in a dimeric form of FabZ that is incapable of substrate binding.
It is likely that the selection of cell clones and their adaptation to various culture conditions may involve alterations not only in cellular machinery directly related to the selected marker or adapted behavior, but also those which may or may not be essential for selection or adaptation.
These alterations not only support the idea that senescence is preceded by an irreversible G1 arrest [30], [36], but also are reminiscent of a common function of herpesviral immediate-early genes, namely to halt cell cycle progression in G1 [18].
These combinations may lead to alterations not only in cellular metabolism but also in survival signal [ 122, 123].
Moreover, biometal alterations not only occur in the central nervous system (CNS), but also peripherally in NCL affected animals.
We now analyzed the entire set of RECQL5-dependent genomic alterations (not only recurring events) to establish whether the associations were generally observed.
In summary, alterations not only in TP53 but along the whole p53 axis lead to decreased overall survival and therapy resistance in CLL.
It has been shown that physical training can induce structural and functional alterations, not only in the skeletal muscles, but also in tendons [ 1, 16, 20– 26].
