The phrase "alteration necessary to" is correct and usable in written English.
It can be used when discussing changes that must be made to achieve a specific outcome or to meet certain requirements.
Example: "The alteration necessary to improve the system's efficiency was implemented last week."
Alternatives: "change required to" or "modification needed to".
Another way of improving LSBs scheme is to reduce the amount of alterations necessary to be introduced into the cover image for data hiding when the number of secret bits is significantly less than that of available cover pixels.
We are currently dissecting the minimal set of genetic alterations necessary to switch on the ability to acquire drug resistance, and dissecting the drug resistance signatures by microarray analysis.
From a cellular viewpoint, the processes related to the water deficit response begin with stress perception, followed by signal transduction, and a change in gene expression that finally confers the complex metabolic and physiological alterations necessary to gain stress tolerance [ 11, 12].
However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies.
A mouse model of human HCC with inducible expression of MYC in adult liver cells has shown that overexpression of MYC is sufficient to initiate HCC development; however, these tumors develop with a prolonged latency, suggesting that other genetic alterations are necessary to generate HCC, including mutations in the p53 pathway [32], [37], [38], [39], [40].
These results may imply that at least six genetic alterations are necessary to convert a normal cell into a fully malignant cancer cell in SCLC.
Thus the ccB signature may reflect the transcriptomic impact of these poor prognosis alterations, but more than one alteration may be necessary to establish this phenotype, and as yet unknown alterations are also likely to contribute.
Each actual deployment fits into this generic picture, although some alterations might be necessary to reflect the actual physical topology.
To exploit these alterations, it is necessary to understand how they define a molecular context that allows increased sensitivity to particular compounds.
These studies are necessary, since we do not know the extent of genetic or epigenetic alterations which is necessary to cause morphologically detectable changes of fractality.
