The phrase "alteration mediated by" is correct and usable in written English.
It can be used in contexts discussing changes or modifications that are facilitated or influenced by a specific factor or agent.
Example: "The alteration mediated by the new policy has significantly improved employee satisfaction."
Alternatives: "change facilitated by" or "modification influenced by".
In the present study, we identified novel molecular alterations mediated by Hp involved in early and late cardiac repair responses after left coronary artery ligation in Hp−/− and wild-type (WT) mice.
The physiopathogeny of PTTN points to both peripheral mechanisms involving neuro-glio-immuno vascular alterations mediated by chemokines/cytokines release and central mechanisms involving both alterations of ascending pathways and descending controls [4 7].
Increases in nucleus accumbens ΔJunD expression can reduce or, with a large increase, even block most of the neural alterations seen in chronic drug abuse (i.e., the alterations mediated by ΔFosB).
In the present study, we utilized an in-vitro model system to examine miRNA alterations mediated by cigarette smoke condensate (CSC) in normal human respiratory epithelia, and lung cancer cells derived from smokers as well as nonsmokers.
The number of known lncRNAs is now rapidly increasing, and experimental evidence for epigenetic alterations mediated by long intergenic noncoding RNAs, a fraction of lncRNAs, is accumulating.
Still, transcriptome-wide approaches will be important to broadly characterize the specific splicing alterations mediated by these proteins across diverse normal and malignant tissues.
Our findings showing transcriptional alterations mediated by chronic exposure to arsenic species in cells lacking functional p53 protein might therefore differ from those seen in cells with functional p53.
Cytoskeletal alterations mediated by microtubule-associated proteins such as members of the tubulin family [ 72] and the microtubule-associated protein Tau [ 73] play an important role in breast cancer cells' metastasis and their cellular levels are affected by p53 [ 72] and the estrogen receptor [ 74, 75] status.
In addition to individual constitutive DNA methylation profiles that could per se be associated with cardiovascular outcomes [ 19], subtle and progressive DNA methylation alterations mediated by lifestyle and environmental exposures may in fact lead to dysregulation of several metabolic pathways during lifetime and ultimately to cardiovascular damage and disease [ 20].
Such cell cycle alterations are mediated by p53 and p21.
