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This stress-induced alteration may represent a state-dependent factor which is reversible.
- DNA methylation is also a pivotal regulator of gene expression., Histone acetylation is deregulated in many neoplasms, human leukemias in particular, where its alteration may represent a common leukemogenic pathway.
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These results suggest that such alterations may represent an important mechanism whereby antioxidants protect against the neurotoxic effects of ethanol in the developing CNS.
This excludes making routine alterations to existing products, processes, and other ongoing operations even though those alterations may represent improvements.
We therefore suggest that WM alterations may represent endophenotypes and neurobiological markers intermediate between the underlying susceptibility genes and the clinical expression of BD.
We suggest that white matter alterations may represent endophenotypes and neurobiological markers intermediate between the underlying susceptibility genes and the clinical expression of BD.
15 Furthermore, underlying diseases, such as hypertension as well as renal and/or hepatic alterations, may represent contraindications to the above-mentioned systemic treatments.
As such, epigenetic alterations may represent one of the key mechanisms underlying the long-lasting nature of ELS-induced changes in neurobiology, behaviour and disease susceptibility [ 22, 23].
These alterations may represent further pathways for redirection of fatty acids into export from the liver or oxidation to prevent liver fat accumulation.
We suggested that white matter alterations may represent endophenotypes and neurobiological markers intermediate between the underlying susceptibility genes and the clinical expression of BD.
This permits speculation about whether these transient alterations may represent processes initiated by the SGs to resolve environmental challenges or to compensate for developmental deficiencies, primarily without involvement of the adaptive immune system.
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