Sentence examples for alteration itself from inspiring English sources

In that case, the snoRNA, cellular level of which rises/drops rapidly, may not play a key role in the pathology, but the alteration itself may indicate tumor progression and reflect metastatic potential [ 37].

Thus, due to its central position, the switch in the CC could respond to a conformational alternation in the upstream domain (the stimulus), only then undergo an appropriate conformational alteration itself, and thereby transmit a signal to allow action of the downstream domains.

Nevertheless, if a molecular alteration is the cause behind celastrol's miR-223 induction, it should meet two requirements, (1) following celastrol treatment, this alteration must happen before miR-223 induction and (2) this alteration itself could regulate miR-223 in our system.

Also, substantial biases due to arsenic exposure would require systematic alterations of methylation states at the 500 L-DMRs in a manner consistent with the linear space spanned by the reference profiles, an event unlikely unless the alteration was itself implicated in perturbations of hematopoiesis.

The British Museum has reconsidered its display of the Elgin Marbles several times over the years, and the evolution of taste illustrated by these alterations is itself of cultural interest.

Alterations manifested itself as distorted reflectance of the fundus, swelling of the retina, the emergence of distinct foci of ischemia, and the signs of atrophy of choriocapillaris and RPE.

In this age of seamlessly altered and composite images, Figure Ground brings the idea of image composite the forefront, making the act of alteration the figure itself".

This last is therefore mainly due to the alteration of the coating itself and to the minor contribution of the residual deposit.

But, "if they were to move [U.S. forces] to more of a front-line and combat role, that would suggest a significant alteration to the strategy itself," said Mandaville.

None displayed any change over 8 days following knockout (6) showing no dramatic functional alteration of the photoreceptor itself upon Otx2 gene ablation.

However, these particular associations with the first and second environmental events are not a necessary component of the Model and, if it turns out that these two factors are not relevant, then two suitable alternatives would simply need to be substituted into the equations without any alteration of the Model itself.