Sentence examples for alteration is established from inspiring English sources

The Richardson case demonstrates that, when actual proof of document alteration is established, trial courts will severely sanction violations in a fashion that makes pursuit of the issue worthwhile for the victim and his or her counsel.

Although the functional implications of these alterations have not been established fully, such changes may be expected to contribute to altered stromal cell function and the generation of a permissive tumor microenvironment.

However, whether MTUS1 corresponds to a "bona fide" tumor suppressor gene inactivated by epigenetic or genomic alterations remains to be established.

The clinical significance of these alterations is yet being established.

Whether these constitute parasite survival mechanisms or in contrast metabolic cytotoxic alterations remains to be established.

The role of the Th17 response in vascular alterations has not been established.

Therefore, a consensus on PCa-specific miRNA alterations has not been established to date.

Unlike nDNA, mtDNA CpG sites are abundant, and a link between cytosine methylation and transcriptional alterations has not been established.

Finally, we did not assess neurocognitive function in this sample, so the functional significance of these hippocampal alterations remains to be established.

However, the clinical relevance of particular alterations remains to be established, as demonstrated by the association of PIK3CA mutations with favorable biological characteristics and improved clinical outcome in early-stage ER+ breast cancer [ 21].

Issues regarding adjustments for multiple testing, statistically significant thresholds, and biologically relevant alteration levels, have not been established for high-throughput DNA methylation studies.