The phrase "alteration irrespective" is not correct and does not convey a clear meaning in written English.
It seems to be an attempt to express a concept related to change or modification without regard to certain conditions, but it lacks clarity and proper usage.
Example: "The project will proceed with the alteration irrespective of the feedback received."
Alternatives: "change regardless" or "modification without consideration".
Notably, the observed T cell alterations occurred irrespective of the initial CLL/T cell ratio and were also recapitulated in T cells from healthy donors.
Empty lentiviral particles generated numerous enzyme expression changes in comparison to uninfected cells, indicating an alteration in antioxidant capacity irrespective of a shRNA target.
Taken together, the combination of retinoic acid and the demethylating agent is recommended for the prevention of recurrence irrespective of alteration of the five proteins in never-smokers with adenocarcinoma.
Mice on a normal chow diet did not show any alterations in liver histology irrespective of the genotype (electronic supplementary material [ESM] Fig. 1).
Such data underscore the need to initiate therapeutic interventions early in childhood to lessen abdominal obesity and insulin resistance and improve the associated adverse alterations in lipoprotein profile, irrespective of race or sex, and reduce the potential risk of atherosclerotic cardiovascular changes.
In addition, RARβ2 hypermethylation may affect RFS irrespective of an alteration of interacting proteins in never-smokers.
Finally, the MPI was prognostic irrespective of somatic alterations in EGFR, KRAS, TP53, and ALK.The MPI incorporates genes expressed in the tumor and its microenvironment and can be implemented clinically using qPCR assays on FFPE tissues.
Irrespective of substrate accessibility, alteration of metabolites results from decreased AA metabolism due to the inhibition of cyclooxygenase (COX) activity [ 120].
Moreover, acoustically-evoked brainstem responses were absent or showed profound alteration in all OPA1-M patients irrespective of the severity of the hearing impairment.
Although the results of these studies showed that some alterations in tooth color are inevitable, irrespective of whether these changes are visually recognizable, in vitro tests may not accurately reflect the clinical situation [ 12].
