Alterations in the spectrum of circular dichroism indicated changes in the secondary protein structure.
Septins may belong to the class of cancer critical genes where alteration in expression profile (including alterations in the spectrum of transcripts expressed) may underpin their role in neoplasia as opposed to specific mutational events.
Despite unchanged (intestine) or reduced (liver) total PL content, major alterations in the spectrum of glycerophospholipids could be detected, particularly in PC species with carbon chain length of C32 and C34.
Both solvents induce several alterations in the spectra.
Most reports focus on classifying samples as safe or contaminated based upon alterations in the spectra determined by multivariate analysis; however, better estimations of mycotoxin concentrations appear promising.
Under some conditions, profound changes in surface morphology may lead to no measurable alteration in the infrared spectrum, while, under other circumstances, variations of only a few percent in the occupancy of different adsorption sites may alter spectra quite massively.
Figure 5 Alteration in the UV vis spectrum and appearance of AuNPs by mixing with PBS and proteins.
Interestingly, wrn/xpa cells exhibited a very similar frequency of TLS usage (Fig. 5E) and no alteration in the mutation spectrum created by the use of TLS compared with xpa cells (Fig. 5F).
For example, a single amino acid alteration in the narrow-spectrum β-lactamase SHV-1 may lead to the emergence of enzymes that can hydrolyze extended-spectrum cephalosporins or even carbapenems [ 4].
