This study demonstrates impaired number-sense in one-third of chronic pain patients, possibly linked to functional alterations in the right PC and PFC.
Previous studies with diffusion-tensor imaging in FM patients showed alterations in the right thalamus and significantly lower fractionated anisotropy compared with controls.
Additional subcortical grey matter alteration was detected in the right posterior thalamus and in the most anterior part of the right putamen.
And the Western blot results indicated that the Nav1.7 expression level changed with behavioral alterations in the rat right hind-paw pain model in SNL groups.
Our effects were specific for the left hemisphere network of executive control of attention and no alterations were found in the right hemisphere networks of alerting and orienting.
Axial diffusivity was also found be increased in widespread white matter regions (p < 0.02, corrected for multiple correlations) similar to those of FA changes, but no significant alteration of axial diffusivity was found in the right parietal lobe in the juxtacortical white matter and the posterior corona radiate (Figure 1 third row).
White matter and grey matter alterations were most robustly co-localized in the right anterior temporal lobe including the most consistently involved white matter tract, the uncinate fasciculus.
The alterations in network topologies primarily occurred in the right superior temporal gyrus (auditory network), and decreased connectivity was observed in the visual network, including the bilateral calcarine sulcus, the bilateral cuneus, and the bilateral lingual gyri.
The amplicon consisted of two parts concerning the copy number alterations (log two values are given in the right panel of Fig. 2C), one distal part with an about 16-fold increase in the copy numbers of the MPV17L and parts of the NDE1 gene and one high level amplified part (up to >100-fold) harboring the MYH11, ABCC1, and ABCC6 genes (Fig. 2C).
It also induced metabolic alterations in several parts of the brain, showing increased glucose metabolism in the right hemisphere.
