Epitopes located on the protein may also undergo alterations in the process.
The causal relation between chromosomal rearrangements and impaired sperm production has been suggested to be a structural effect related to alterations in the process of chromosome synapsis during meiosis [21], but whether submicroscopic chromosomal rearrangements (CNVs) can result in meiotic recombination defects is not known.
Thus, alterations in the process of chromatin assembly during transcription can destabilise H3 nucleosomes and thereby allow CENP-ACnp1 to assemble in its place [ 47 ].
The unsupervised strategy enabled us to set an internal standard to validate clustering results; the copy number profiles in samples of the same tumour should be more similar than any copy number profiles from another tumour because the gene alterations in the process of carcinogenesis are largely common among the samples from the same tumour.
Interestingly, studies of human brains (Tatebayashi et al. 2003) and tg animal models have demonstrated significant alterations in the process of adult neurogenesis in the hippocampus in AD (Dong et al. 2004; Jin et al. 2004; Wen et al. 2004; Chevallier et al. 2005; Donovan et al. 2006).
Over the past several years, many TSGs have been found to be epigenetically inactivated in gastric cancer, indicating that epigenetic silencing of TSGs is one of the major molecular alterations in the process of gastric carcinogenesis (Lee et al, 2002; To et al, 2002; Choi and Wu, 2005; Chan and Rashid, 2006; Sato and Meltzer, 2006; Cheng et al, 2007).
Constitutive overexpression of cyclin E in both immortalized rat embryo fibroblasts and human breast epithelial cells induces chromosomal instability without changing centrosome numbers but while impairing S phase progression, pointing to possible alterations in the process of licensing the origins of DNA replication [ 23].
Persistent malnutrition, sedentary lifestyle and obesity have been associated with alterations in the processes that regulate the control of blood pressure and the action of insulin on the metabolism of carbohydrates and lipids.
It is not clear whether the association of HPV16 capsid antigen positivity with smoking is also accompanied by an alteration in the pathological process of infection.
Others and we believe that part of this endothelial dysfunction present in the preeclamptic placenta may include alteration in the angiogenesis process [ 3, 4, 14, 29, 38], which in turn could explain the elevated risk for short and long term complications observed in children exposed to preeclampsia intrauterine.
