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The alteration in the formation of [14C]glucose-labeled lipids was not caused by a deficient uptake of glucose because we observed no changes in the rate of [3H]deoxyglucose uptake in cells treated with CVT or vehicle (Figure 4D).
Such increase in the cellular uptake was explained by the topography-induced alteration in the formation of densely packed actin filaments which affected the cellular contractility and upregulation of the Rho-GTPase pathways.
Our results indicate that nickel sulfate affects the steroidogenic enzymes, causing alteration in the formation of testosterone in both dietary groups, which was manifested in the elevated cholesterol and ascorbic acid level with decreased activities of steroidogenic enzymes in adult rats testes.
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Part of this variance may reflect time-dependent ruminal adaptations to high levels of lipid in the diet, which lead to alterations in the formation of specific biohydrogenation intermediates.
We propose that the enhancement of microtubule dynamics may explain the alterations in the formation of focal adhesions, leading to inhibition of cell adhesion and migration.
Interestingly, we also show that MVL-PLA2 enhances microtubule dynamics likely leading to the alterations in the formation of focal adhesions, which may explain its effect on angiogenesis.
Therefore, alterations in the formation of three-dimensional structures might activate the EGFR pathways.
Such preferential use of DHA would inhibit cell survival and proliferation, due to alterations in the formation of cell membrane lipid rafts [ 47– 47].
At the subcellular level, our studies indicated that the suppression of TBPH provoked evident defects in the anatomical organization of the peripheral glia with morphological alterations in the formation of the cytosolic projections that cover the synaptic surface of the presynaptic terminal axons that constitute the NMJs (11, 22).
showed meiotic and postmeiotic alterations in the formation of the male gametophyte, which could be due to its polyploid nature (5x = 150), and these alterations might be responsible for the high sterility of pollen grains of this species (66.4%), on the contrary, A. tequilana is a diploid with 2n = 60, however, it had a high percentage (42.00%) of nonviable pollen grains.
To investigate whether this apoE4-induced decrease in spine density results from alterations in the formation or the loss of dendritic spines, the effects of neuron age and apoE isoform on the total number and subclasses of spines were examined in long-term wild-type neurons co-cultured with glia from APOE2-, APOE3- and APOE4-TR mice.
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