Sentence examples for alteration in synaptic from inspiring English sources
Long Term Potentiation (LTP) is thought to represent one form of durable alteration in synaptic strength underlying memory formation[1].
At the moment, most studies point towards an alteration in synaptic transmission, in a neuromodulatory-type effect [ 7, 8].
A RG specific knockdown of Opa1 (Deng et al., 2008; Poole et al., 2010) causes a very similar alteration in synaptic morphology as Marf knockdown.
Stepdown ANOVA to further explore the effects of intensity and IPI revealed that the alteration in synaptic inhibition occurred at the 20% [ F 3, 301) = 10.17; p < 0.0001] and 50% [ F 3, 311) = 5.59; p < 0.0010] stimulus intensities.
Previous studies have found reduced cognitive function with reduced neuronal activation following sleep loss in the PFC [ 9] and indicated that sleep loss induces alteration in synaptic plasticity and membrane excitability in the cortex [ 10], which might be modulated by dopaminergic system.
It is convenient to consider three components of LTP (and LTD): induction (the trigger mechanism); expression (what changes to result in an increase (or decrease) in synaptic transmission; and transduction (the signalling cascades that lead from induction to expression and maintain the alteration in synaptic efficiency).
It would be interesting to investigate whether JNK signalling is altered in loss-of-function mouse models where alterations in synaptic activity have been speculated to be a possible root cause of Batten's disease.
Apart from its effects on microtubule binding, phosphorylation can alter tau subcellular localization to dendritic spines (127) or can alter its affinity for the plasma membrane (128), thereby causing alterations in synaptic function (127, 129).
Additionally, iPSC-derived neurons may provide insights into alterations in synaptic plasticity implicated in the pathophysiology of other neurogenetic disorders.
The alterations in synaptic transmission observed in the present study were accompanied by morphological changes of hippocampal synapses.
These abnormalities result in corresponding alterations in synaptic transmission with reduced quantal content.
