Sentence examples for alteration in specific from inspiring English sources

Alteration in specific components of the PI3K signaling pathway, such as PDK1, leads to an impaired transition from DN to DP thymocytes, suggesting an essential role of factors downstream of PDK1 in T cell development.

In the previously cited reference Lukiw reported that: "miR-9, miR-124a, miR-125b, miR-128, miR-132 and miR-219 are abundantly represented in fetal hippocampus, are differentially regulated in aged brain, and an alteration in specific micro-RNA complexity occurs in Alzheimer hippocampus".

While Dex-induced muscle atrophy selectively affects fast fibers, there are no gross changes in architecture which may explain the lack of alteration in specific force.

We selected mutants in three additional genes encoding GH family 61 enzymes (NCU02240, NCU07898 and NCU02344) and one GH family 11 hemicellulase (NCU02855) belonging to cluster 2 (up in Δ vvd) for further analysis; no significant alteration in specific cellulase gene expression was observed for mutants in any of the three GH 61 family cellulases.

Previous studies of trisomic mice for the same region (Ts1Yah) showed a complex cognitive phenotype that combined alteration in specific domains that are affected in well-characterized DS models such as nonassociative learning and short-term spatial and recognition memory (Lopes Pereira et al. 2009).

In the experiments, we first show the limitation of the enrichment analysis and current network-based analysis on DNA copy number, and then demonstrate that, although there are distinct patterns of copy number alteration in specific types of cancer, our method can identify common pathways disrupted in more than 10 different types of cancers.

When tumor progression requires alterations in specific oncogenes (oncogene addiction), drugs that selectively block their products might slow tumor growth.

Neuroreceptor ligands applicable to PET imaging could provide tools to investigate alterations in specific neurotransmissions under pathological conditions and to quantify the receptor occupancy by therapeutic agents.

This method allows identifying individuals in whom symptoms are explained by preceding alterations in specific stress biomarkers, based on time series of symptoms and stress biomarkers.

Native polyacrylamide gel electrophoresis (PAGE) of SOD, CAT and POD also displayed increased enzymatic activity along with associated alterations in specific isoforms.

Of these, aCGH is highly useful to detect copy-number variations (CNVs) in the genome of individuals with apparently normal karyotypes [5,6], and MLPA can identify various copy-number alterations in specific disease-associated loci [7].