Sentence examples for alteration in prostate from inspiring English sources

Fusion of the prostate-specific and androgen-regulated transmembrane-serine protease gene (TMPRSS2) with the erythroblast transformation-specific (ETS) family members is the most common genetic alteration in prostate cancer.

Fusion of the androgen-regulated gene transmembrane protease, serine 2, TMPRSS2, to the v-ets erythroblastosis virus E26 oncogene homolog (avian), ERG, of the erythroblast transformation-specific (ETS) family is the most common genetic alteration in prostate cancer (PCa).

ETS-related gene (ERG) oncogenic activation is the most common genomic alteration in prostate cancer (CaP) although it occurs less frequently in African American (AA) versus Caucasian (CA) patients, and the potential role of ERG as a prognostic marker has not been confirmed.

In 2005, Tomlins et al. identified the fusion of two genes, ERG and TMPRSS2, as a common somatic alteration in prostate cancer (PCa) [ 1].

This chromosomal rearrangement is a highly prevalent oncogenic alteration in prostate tumor cells and leads to an aberrant expression of the ERG proto-oncogene, important for early prostate carcinogenesis [ 57].

As the TMPRSS2-ERG fusion is the most common genomic alteration in prostate cancer, and cell migration is a key component of metastasis, the high-affinity ERK2/ERG interaction represents a potential target for small molecule inhibition during prostate cancer treatment.

Filtering for putative alterations in prostate cancer pathogenesis may begin with altered protein expression, but much like at the transcriptome level, this must be qualified and validated.

Yu, Y. P. et al. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy.

Mao, X. et al. Distinct genomic alterations in prostate cancers in Chinese and Western populations suggest alternative pathways of prostate carcinogenesis.

Williams, J. L., Greer, P. A. & Squire, J. A. Recurrent copy number alterations in prostate cancer: an in silico meta-analysis of publicly available genomic data.

Next-generation sequencing studies have led to significant advances in our understanding of genomic alterations in prostate cancer.