Meprin α1 knockdown animals showed relatively mild, but clearly distinct alterations in comparison to wild type animals (Figure 2C, A respectively). 44% of the injected embryos revealed a dilated pericardium or a distorted trunk and tail tissue, probably due to disorders in cell differentiation (Figure 2F).
The epigenome of cancer cells displays numerous alterations in comparison to the epigenome of their normal counterpart.
Cells treated with lemon grass essential oil at MIC level underwent considerable morphological alterations in comparison to the control when observed by a Scanning Electron Microscope.
In general, examination of allelic ratios of RAS-pathway alterations in comparison to cellularity estimates suggested that RAS-pathway mutations may be more likely to be hemizygous or homozygous (Additional file 1) although copy number analysis was not available to validate this.
Genetic redundancy of the EXO/ EXL genes could account for the relative mild phenotypic alterations of exo in comparison to BR-deficient or BR-insensitive plants.
Maltonis was screened for its ability to induce structural alteration of DNA molecules in comparison to another maltolic molecule (malten).
However, the sublingual mucosa exhibited the most pronounced alterations of microcirculatory flow in comparison to conjunctival, jejunal and rectal mucosa microvasculature (P < 0.05).
In addition, we have studied transcriptome data from rectal suction biopsies, as first, intestinal epithelium expresses large amounts of CFTR and second, owing to the high turnover rate of epithelial cells in the intestine, these samples are less prone to secondary alterations by inflammatory processes in comparison to pulmonary tissue.
In the present study, PC-3 cells treated with (a) IL-13, IL-1 β, IFN- γ, or TNF- α, (b) the inhibitors UO126, SB203580, SP600125, LY-294002, or BAY 11-7082 and (c) the combinations of IL-13, IL-1 β, or IFN- γ with these inhibitors did not show statistically significant alterations of cell death in comparison to the control.
