The phrase "alteration in combination" is correct and usable in written English.
It can be used in contexts discussing changes or modifications that occur when different elements are combined or integrated.
Example: "The alteration in combination of the ingredients resulted in a unique flavor profile that surprised everyone."
Alternatives: "change in conjunction" or "modification in combination".
The elucidation of genetic alterations in combination with the development of high-throughput sensitive techniques should lead to the discovery of effective biomarkers for early detection of this malignancy.
By analysing the DNA copy number alterations in combination with transcripts expression array we could identify the genes that are strong candidates for contributing to PPP tolerance.
Analyzing these alterations in combination may therefore provide deeper insight into the pathobiology of the disease, while also generating panels of markers that may be able to better predict patient outcome and treatment response.
These alterations, in combination or individually, make it possible to establish the methylation profiles, histone modification maps, and expression profiles characteristic of this pathology, which become useful tools for screening, early detection, or prognostic markers in cervical cancer.
While such changes often have no effect, some alterations in combination with the environment of the cells that harbor them, conspire to initiate and maintain a tumorigenic process resulting in abnormal cell proliferation.
It is anticipated that climate change impacts and subsequent environmental alterations, in combination with the effects of anthropogenic stressors, will have dramatic consequences for biodiversity, community composition and the level of ecosystem functioning [ 1, 2].
These design alterations are examined in combination with an appropriate control concept that improves the FRT behavior of the DG-PV units.
As a result of these experiments, we have established a series of transformed and non-transformed Barrett's epithelial cell lines that can be used to elucidate the contribution of specific genetic alterations, alone and in combination, to carcinogenesis in Barrett's esophagus.
