Sentence examples for alteration in cellular from inspiring English sources

This enzymatic deficiency, similar to other lysosomal enzyme deficiencies, leads to alteration in cellular architecture.

In addition, direct alteration in cellular respiration with mitochondrial dysfunction also was advocated [13], and, finally, Tavernier et al. suggested that increased phosphorylation of troponin I was involved by reducing myofilament response to Ca2+ [14].

However in a significant fraction of human tumors, the p53 pathway is inactivated through alteration in cellular components acting up- or down-stream of p53.

Nascent virus induces a profound alteration in cellular membrane organization and anterograde transport, subcellular systems known to be required for neuronal function and survival.

One potential reason for the differences in sensitivity to CDDP is related to an alteration in cellular uptake of the DNA damaging agent.

While most point mutations showed no significant alteration in cellular localization, one, S285I (Figure 1), showed a significant defect in nuclear localization (p<0.0001; Table 1).

The presence of transcription factor proteins in the cargo of neoplastic cell-derived exosomes may allow for distant cell alterations in cellular transcription, resulting in altered signaling of both normal and cancer cells.

Multiple mechanisms may contribute to sepsis-associated organ dysfunction, which is related to altered tissue perfusion, especially in the early stages, and to direct alterations in cellular metabolism.

For example, hydrogen bond formation, or deformation, can cause drastic alterations in cellular reaction.

However, other sensors can be expected resulting from physical alterations in cellular structures induced by metal exposure.

From a pathophysiologic perspective, ischemia and the associated tissue hypoxia leads to cell death, which are mediated by fundamental alterations in cellular homeostasis.