Genomics influences electrical and chemical dynamics producing local and global network effects with alterations in behavior.
Administration of the N-methyl-d-aspartate (NMDA) antagonist phencyclidine (PCP) may produce alterations in behavior that resemble those that have been observed in animal models of schizophrenia.
Because the data being collected in the gym environment is not as standardized, this data is qualitative, case study in nature, but we do think it shows the effects of such alterations in behavior.
Also, after the first week of exposure, animals from the treated group G4 (1 mg/L) presented colored skin and alterations in behavior during feeding, such as continuous exposure of the pharynx and limited mobility.
Using a range of tests we have studied alterations in behavior with advancing age in female C57BL/6 (of Jackson origin), the golden standard on which most genetically engineered mice are back-crossed.
Results indicated that exposure to 56Fe particles can produce alterations in behavior and neuronal signaling and that these alterations may be more apparent in older organisms, a finding which suggests that the aging brain may be more susceptible to the deleterious effects of irradiation on performance.
As described above, feeding flies hydrogen peroxide caused an increase in activity and alterations in behavior, beginning approximately 11 minutes after first exposure.
Two experiments were conducted to measure the alterations in behavior, cFos expression and neurotransmitter content due to fear conditioning and ketamine and/or antipsychotic administration.
We further hypothesized that such alterations in behavior, and the associated modifications in brain gene expression profiles, would be transmitted to the offspring, thereby suggestively prepare the offspring for the parental environment.
Our results escalate this surprise further as genetic deletions of the neuronal enzyme TPH2 and the combination of TPH1 plus TPH2 enzymes also produced viable mice with relatively subtle alterations in behavior.
