After assembly of these barcodes into genome-wide physical maps, complex genome structure is revealed, characterizing genomic alterations, in addition to providing scaffolds for genome sequence assembly, or validation.
In wt neu-expressing mice under the MMTV promoter, focal mammary tumors arise next to hyperplastic mammary tissue after a long latency period (17 48 weeks) [3], suggesting that genetic alterations in addition to that inducing HER2 overexpression are required for mammary transformation.
Identification of molecular alterations in addition to BRAF may help explain why resistance develops more quickly in some patients, and suggest rationale strategies to overcome resistance.
These data suggest that the effects of a mutationally activated FLT3 receptor may be different, depending on a primary genetic alteration or the composition of different genetic alterations in addition to the FLT3-LM.
To prove that FADD deficiency is responsible for loss of TRAIL-induced activation of NF- κB in FADD-deficient JURKAT cells, a rescue experiment was performed, as they might have acquired further alterations in addition to loss of FADD expression.
Moreover, epigenetics includes several other alterations in addition to miRNA interference such as DNA methylation, histone modifications and chromatin modifications that may be useful to investigate and better characterise fBC and in particular gender-associated epigenetic patterns.
The low frequency of bivalents found in these hybrids, suggesting that structural alterations in addition to centric fission have occurred in P. callosum and P. glaucophyllum, thus hindered their chromosomes from homoeologous pairing with P. delenatii.
These cells have accumulated a number of other oncogenic alterations in addition to and presumably prior to Smad4 inactivation [ 6, 7], likely explaining the TGF-β resistance of Smad4 re-expressing derivatives.
