Importantly, a single alteration in a regulatory system component could alter expression of hundreds of genes.
Insulin is a lipid-synthetic hormone, thus alteration in a gene regulating insulin gene transcription may alter lipid metabolism as well and contribute to dyslipidemia.
Insulin is a lipid-synthetic hormone, thus alteration in a gene regulating insulin gene transcription may alter lipid metabolism as well and contribute to hypercholesterolemia. Furthermore, overexpression in transgenic mice of the coactivator Bridge-1, homologous of PSMD9, results in elevated triglyceride levels in Bridge-1/PSMD9 with severe diabetes compared to non-transgenic control mice [ 10].
As conceptualized in contemporary neurobiological models (Craig, 2002, 2009) and illustrated by the present behavioural data, these are complex psychological constructs: alteration in a patient's responsiveness to pain or temperature variations might reflect altered awareness, tolerance, motivation, behavioural organization or some interaction of these, all potentially dissociable processes.
The rate of the chromosome alteration in a group of normally developing people was one in 10,000.
One single alteration in a timeline does not necessarily change everything.
Time is an aspect of change, where change means an alteration in a dynamic network of relationships that define the world.
However, I have not been able to shake off the distress at the alteration in a relationship that I cherished, and a sense of betrayal that she put her career above our friendship.
Genetic marker, any alteration in a sequence of nucleic acids or other genetic trait that can be readily detected and used to identify individuals, populations, or species or to identify genes involved in inherited disease.
The book seems less about a Chinese-American protagonist's real clash and alteration in a real America -- as, for example, in Gish Jen's novels and stories -- than about the wavering sense and feeling that render his America into a partial phantasmagoria.
In 1949 American chemist Linus Pauling and colleagues demonstrated that a mutation causes a structural alteration in a protein; hemoglobin (the protein in red blood cells that carries oxygen to the tissues of the body) extracted from normal human red blood cells was shown to behave differently from hemoglobin taken from persons with the hereditary disease sickle-cell anemia.
