The phrase "alteration frequency" is correct and usable in written English.
It can be used in contexts related to changes or modifications occurring at a certain rate or interval, often in scientific or technical discussions.
Example: "The alteration frequency of the genetic material was measured to understand the rate of mutations."
Alternatives: "change rate" or "modification frequency".
ERK and PI3K/AKT have been identified as the two most commonly altered pathways in prostate cancer with alteration frequency of 42 43 % in primary and 90 100 % in metastatic prostate cancer [ 148].
Modules were visualized as discrete colors and gene alteration frequencies were visually resized in proportion to alteration frequency across the 84 analyzed GBM cases.
An alteration frequency score for each gene was calculated, based on the 84 GBM cases with both sequence mutation and copy number data (hypermutators excluded).
Pearson correlations were calculated by weighting the alteration frequency of each locus on a linear scale.
These two closely located (within a 39.8 kb region at 10q24.1) candidate genes, showed alteration frequency of 57.5% with gain of gene copy number in Asian (Table 1A), whereas the alteration frequency was only 20% in Caucasian patients.
The graph shows the alteration frequency, either in CN or in GE independently, along all the genome (22 human chromosomes).
However, by ranking the pathways according to their variability in alteration frequencies between cancers, we identified several pathways that were altered very frequently within one or few cancer types and only rarely in other cancers.
Although several genes involved in Wilms' tumour have been identified, as described above, the alteration frequencies of these genes (loci) and how many loci are altered in the tumour are still unknown.
Correlations were tested using the Pearson correlation analysis based on the data for alteration frequencies calculated based on the AFLP and MSAP variant frequencies and altered gene expression.
Alteration frequencies were compared using the Fisher's exact test and false discovery rate (FDR) was applied to correct the multiple testing hypothesis (p<0.05) [51].
Alteration frequencies and frequency differences in MSS samples are shown in Figure 1.
