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One compact figure can represent all somatic alteration events in a given tumor sample.
Excessively present in myeloma, CNAs are also frequent genomic alteration events in most hematological cancers and many solid cancers [ 4].
Loss of the corresponding locus (CDKN2A) is among the most frequent cytogenetic alteration events in human cancer [ 82].
Our results indicate that Dissect has high sensitivity and specificity in identifying structural alteration events in simulated transcripts as well as uncovering novel structural alterations in cancer transcriptomes.
Categorization of the alteration events in a cancer cell population could influence the therapeutic decision, and requires a simultaneous exploratory view of all the alteration events.
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Further analysis of this 9p13 alteration event in oral cancer initiation and progression is warranted.
Among the top 10 hub features, 7 of them were copy number alteration features, supporting the significance of copy number alteration event in cancer progression and treatment.
These observations imply that diverse carcinogenic implementations and functional genetic alteration events exist in different pan-cancer subgroups, depicting essential tumor heterogeneity.
This recurrent alteration event has been validated using fluorescence in situ hybridization in an independent set of OPLs.
DNA methylation alterations are early events in tumorigenesis and important in the regulation of gene expression in cancer cells.
We conclude that CDKN2 gene alterations are rare events in human ovarian cancer.
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