The phrase "alteration down" is not correct and does not convey a clear meaning in written English.
It is unclear when to use it, as it lacks context and does not form a recognizable expression.
Example: "The alteration down of the design was unexpected." (This example is awkward and unclear.)
Alternatives: "reduction in" or "decrease in".
One point that needs further investigation is whether this alteration (down-regulation) occurs as an early/late consequence of the disease, or may act as a susceptibility factor that influences the onset of the pathology.
Expression arrays showed that about 4% of the Drosophila genome altered in expression and about half of the alteration was down-regulation.
Indeed, DF-1 cells retain various genetic alterations of down-regulated p53 function, an up-regulated pRB (retinoblastoma protein) and E2F1 pathway, and elongated telomere length, which are commonly found in immortalized cells [ 19].
If there is a silver lining to be found in this legislation by those suffering from non-terminal but intolerable and incurable disease, it may rest in the fact that the government hasn't shut the door to legislative alterations down the road-we can only hope the Charter becomes the force by which that door is blown wide open.
This approach enables us to detect both large-scale and gene-size copy number alterations down to ~35 kb in size.
The applied variant filtering strategy narrowed the number of shared heterozygous alterations down to a single missense variant in the LZTS1 gene which was found to segregate with the disease phenotype.
The aim of this study is to put forth novel biological networks that describe transcriptional alteration (up and/or down-regulation) in genes/pathways which could contribute to the pathogenesis of T2D and its associated complications.
Functional alterations include down-regulation of oestrogen and progesterone receptors as well as cell proliferation (Critchley et al., 1998b; Salmi et al., 1998).
It was expected that genes that were transcriptional targets of HIPPI would show a reduced level of alteration in HIP1 knocked down cells.
This indicates a loss of epithelial differentiation in ccRCC because the top-rated biological alteration is a down-regulation of pathways that are related to normal renal epithelial function.
The most remarkable alteration was the down-regulation of genes associated with mitosis in the SW480 cell line, accompanied by the induction of binucleation.
