Sentence examples for alteration data were from inspiring English sources
GALNS gene alteration data were gathered from the primary reports.
One of the most successful approaches to discerning the signal in mutation data or in copy number alteration data is to seek out those genes or regions which are altered at a frequency above a background random model.
For identification of DNA copy number alterations, data were smoothed using a local polynomial adaptive weights smoothing procedure for regression problems with additive errors (Hupe et al, 2004; Natrajan et al, 2006).
Copy number alteration (CNA) data were obtained from cBio Cancer Genomics Portal in order to use the results of GISTIC which attempts to identify significantly altered regions of amplification or deletion across sets of patients [ 36].
As a control of the specificity of STOX1-induced transcriptome alterations, our data were compared with a study where mid-gestation versus normal term placentas were analyzed by microarray analysis [11].
TCGA breast cancer mRNA gene expression, copy number alteration, and clinical data were downloaded from UCSC cancer browser at https://genome-cancer.ucsc.edu/proj/site/hgHeatmap/ (data processed in August 2014).
For large-scale alterations, the CGH data were averaged for sliding windows of 130 kb over the relevant chromosomes.
The Kaplan-Meier curves for these analyses are shown in Fig. 3. To further validate the ability of our algorithm to classify tumors into biologically relevant genomic groups, an independent set of 71 NSCLC tumor samples was profiled for copy number alterations, and the data were segmented.
Alteration of data is strictly controlled.
Copy number alteration (CNA) data was obtained from cBio Cancer Genomics Portal in order to use the results of altered regions of amplification or deletion across sets of patients from GISTIC algorithm [ 28].
Results revealed that Hyperion data prove to be powerful in discriminating and mapping various types of alteration zones while the data were subjected to adequate pre-processing.
