The phrase "alteration copy" is correct and usable in written English.
It can be used in contexts where a document or item has been modified or changed from its original version.
Example: "Please review the alteration copy of the contract to ensure all changes are accurately reflected."
Alternatives: "revised copy" or "modified version".
This jeopardizes the detection of two important classes of alteration: copy-neutral and deletion-associated LOH.
Molecular genetic studies of lung cancer have revealed that clinically evident lung cancers have multiple genetic and epigenetic abnormalities, including DNA sequence alterations, copy number changes, and aberrant promoter hypermethylation.
Taken together, the data suggest that genetic and epigenetic alterations (copy number alterations and DNA methylation alterations) are not mutually exclusive during urothelial carcinogenesis.
Moreover, large scale sequencing studies have revealed the various intragenic alterations, copy number variants and chromosomal rearrangements that characterize the many distinct types of cancer [ 48].
Therefore, there was a marked increased frequency of alterations in copy number alterations in six of the thirty SLE samples, consistent with genomic instability.
Alteration of copy number for Chr1, 2 and 3 are represented at similar frequencies based on the average copy number alteration of all five chromosomes, with Chr4 and 5 alterations being, respectively, over- and under-represented.
It is known that mutations or alteration in copy number are related to cancer and tumour development [33], [34].
Alteration in copy number (CNA) are known to locally influence the MeDIP signal (Robinson et al., 2010b).
Genes whose expression levels do not change despite alterations in copy number are termed "dosage insensitive".
Alterations in copy number were widely shared, suggesting they occurred early in carcinogenesis, while point mutations appeared to evolve gradually over a longer period of time.
As seen with other types of cancer, ALL carcinomas were characterized by distinct clonal populations of cells where alterations in copy number preceded the occurrence of SNVs.
