These alterations consist of DNA methylation and histone modifications, with the involvement of noncoding RNA.
Results: The results showed that endothelial cells from preeclamptic placentae express various and severe alterations, consisting of swollen and bulbous cytoplasm, degenerated inter-endothelial junctions with consequent crossing of fetal blood cells outside the vessels.
The epigenetic alterations consist of histone modification, DNA methylation, and microRNA (miRNA) regulation.
Moreover, cardiac alterations consisting of a hypertrophic left ventricular posterior wall and decreased left ventricular chamber dimension were described.
Furthermore, the drug induced ultrastructural alterations, consisting of perinuclear cisternae swelling, chromatin condensation, nucleolar segregation and cytoplasmic vacuolations.
The study confirmed that cisplatin induces dose-dependent cochlear alterations consisting of cellular lesions and significant hair damage in outer hair cells.
ATO/BSO-induced mitochondrial apoptosis is caused by successive BIMEL alterations consisting of phosphorylation, dissociation from MCL1, and interaction with BAX.
Corticosteroid-associated ON showed peculiar alterations, consisting of a decrease in protein C and in an increase in D-dimer relative to healthy controls.
Neuroblastic tumours without MYCN amplification are characterised by combinations of non-random genomic alterations consisting of numerical chromosome variations on the one hand, and segmental chromosome imbalances related to unbalanced translocations on the other hand.
The majority of TP53 alterations consists of missense mutations within the DNA-binding domain (DBD) that lead to the synthesis of p53 proteins that have lost the ability to bind to sequence-specific DNA recognition elements.
