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However, in order to support the diet-induced acidosis hypothesis of osteoporosis, it would seem necessary to objectively measure whether diet alters blood acid base equilibrium, and, particularly, whether such alteration can be found in association with bone fragility.
Using these probabilites, recurrent regions (over sets of individuals) of copy number alteration can be found.
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Both alterations can be found in the tumors and each one can promote tumorigenesis by independent processes.
In a pilot screen we demonstrate that anterior segment and fundus alterations can be found in living adult zebrafish carrying novel (induced) genetic mutations.
Underlying molecular alterations can be found at the DNA level, e.g. copy number variation and sequence mutation, at the transcriptional level e.g. regulatory or posttranscriptional changes or involve translational or posttranslational modification of proteins.
Similar types of alterations can be found on different continents.
We see this also with the example of the prfH gene here, where different obviously disabling alterations can be found.
However, the epithelial morphology was completely lost in passage 5. Already in passage one morphological alterations can be found in some parts of the monolayer.
The mutations can be in the form of small or large deletions, point mutations, or amplifications and these alterations can be found both in the intra- and extracellular parts of EGFR (Fig. 1).
As progress of dysplastic hepatocytes to HCC might occur simultaneously in different foci or nodules, variable genomic alterations can be found within the same liver indicating a genetic heterogeneity of lesions (Feitelson et al, 2002).
Currently, there are no specific biological or morphological markers to establish per se the diagnosis of the CFS, and therefore none of the alterations that can be found are useful for diagnosis.
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